Results: ZZKZ promoted weight gain, food intake, gastric emptying, and intestinal propulsion in FD rats. Particularly, the role of 5-HT in the action of ZZKZ in improving gastric dysmotility and hypersensitivity was explored. Ex vivo gastric smooth muscle activity recordings and greater splanchnic afferent (GSN) firing recordings were employed to evaluate gastric motility and sensation. Body weight gain, food intake, gastric emptying, and intestinal propulsion were also measured. The FD rats were treated with ZZKZ (0.5 g/kg, 1.0 g/kg, or 1.5 g/kg respectively) by gavage for 7 days, while domperidone (3 mg/kg) acted as treatment control. Materials and methods: FD was induced in Sprague-Dawley rats by neonatal gastric irritation with 0.1% iodoacetamide.
, Bupleurum Chinense DC, and Crataegus Pinnatifida Bunge, which have been widely used in clinical therapy for functional dyspepsia (FD).Īim of the study: This study aimed to evaluate the pharmacological effects and mechanisms of action of ZZKZ on gastric hypersensitivity and motor dysfunction in a rat model of FD. ZZKZ contains four botanical drugs, including Citrus × Aurantium L, Atractylodes Macrocephala Koidz.
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